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ABSTRACT

Nature 2001 May 31;411(6837):603-6

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease.

Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, Achkar JP, Brant SR, Bayless TM, Kirschner BS, Hanauer SB, Nunez G, Cho JH.
Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract, which is thought to result from the effect of environmental factors in a genetically predisposed host. A gene location in the pericentromeric region of chromosome 16, IBD1, that contributes to susceptibility to Crohn's disease has been established through multiple linkage studies, but the specific gene(s) has not been identified. NOD2, a gene that encodes a protein with homology to plant disease resistance gene products is located in the peak region of linkage on chromosome 16 (ref. 7). Here we show, by using the transmission disequilibium test and case-control analysis, that a frameshift mutation caused by a cytosine insertion, 3020insC, which is expected to encode a truncated NOD2 protein, is associated with Crohn's disease. Wild-type NOD2 activates nuclear factor NF-kappaB, making it responsive to bacterial lipopolysaccharides; however, this induction was deficient in mutant NOD2. These results implicate NOD2 in susceptibility to Crohn's disease, and suggest a link between an innate immune response to bacterial components and development of disease.


PARA's SUMMARY

NOD-2 IS IDENTIFIED AS THE CROHN'S DISEASE SUSCEPTIBILITY GENE. AGAIN, NOD-2 IS RESPONSIBLE FOR THE ABILITY OF CELLS TO RECOGNIZE A PATHOGEN AND FIGHT IT OFF. THIS SUGGESTS THAT CD PATIENTS DO NOT HAVE THE ABILITY TO FIGHT OFF CERTAIN INFECTIONS (I.E. MAP) AND MOUNT AN APPROPRIATE IMMUNE RESPONSE, WHEN COMPARED TO THE NORMAL POPULATION. THIS STRONGLY SUGGESTS THAT CD IS IN SOME WAY LINKED TO A BACTERIAL PATHOGEN FOR INITIATION OF THE DISEASE PROCESS.


Source: http://www.crohns.org/articles/2001_05_603-6_n.htm   Contact PARA: http://www.crohns.org/contact.htm
Paratuberculosis Awareness & Research Association